It's highly likely that the competency that a Biden team brings to the federal level will get a handle on Covid. That alone will spark an economic boom similar to post WWII. Those two items will spell the death knell of the the Republican party as it now exists. Demographics will take it from there.
They're fighting for their lives and they don't really stand a chance. All they had these last four decades was the promise to "drown government in a bathtub". They almost succeeded. Now, most of America wants to see some competency in government again.
Politics is a big slow ship. It doesn't pivot on a dime. Biden is exactly the right interim captain before a new wave of progressivism takes the wheel.